Abstract
Author(s): Sagar Kakasaheb Jadhav
Quinoxaline is the subject of considerable interest from both academic and industrial perceptive. Among the various classes of the nitrogen containing heterocyclic compounds quinoxaline are the important component of several pharmacologically active compounds. The starting compound quinoxaline,2,3-diol was prepared from o-phenylenediamine and diethyl oxalate. The quinoxaline 2,3-diol upon refluxing with POCl3 gives 2,3-dichloroquinoxaline, 2-chloro-3-hydrazinoquinoxaline was synthesized by reaction of 2,3-dichloroquinoxaline and hydrazine hydrate in methanolic medium. The Schiff's bases of 2-chloro-3-hydrazino quinoxaline were obtained by refluxing the furfuraldehyde and Thiophene-2-carbaldehyde with 2-chloro-3-hydrazinoquinoxaline in acetic acid medium. The progress of reaction was monitored by TLC. The synthesized compounds were characterized by their physical and IR and NMR spectral data.
