Abstract
Author(s): Pralhad Vinay Rege, Vaibhav Madhukar Wagh
In present study, a successful attempt has been made to developa simple method for the simultaneous determination of Levofloxacin and ornidazole using Differential Pulse Polarography (DPP) technique. Quantification of levofloxacin and ornidazole was done in BrittonRobinson Buffer of pH 7.0 using1M KCl as a supporting electrolyte. Both levofloxacin and ornidazoleexhibit reductioncathodic peak in given pH with peak potential at -1.30Vfor levofloxacin and -0.45V for ornidazolevs. S.C.E.0.1N acetic acidwas used as Solvent for the analysis. Proposed method was found to be simple, precise, and accurate andcan be successfully applied for routine quality control analysis andsimultaneous determination of levofloxacin and ornidazole in combined drug formulations. The proposed methodhas been validated. The limit of detection for levofloxacin in the standard solution was 0.12 μg/mland in urine was 0.59μg/mlwhile for ornidazole in the standard solution was 0.24μg/mland in urine was 1.16 μg/ml.
