Abstract
Author(s): Nilesh Mahadeo Khutle1, Harshal Ashok Pawar*,2, Vishakha Vishwanath Doke3, Laxmi Shashidhar Joshi4
Self-nanoemulsifying drug delivery system (SNEDDS) of Telmisartan was developed with an objective to overcome problem of its poor solubility, less bioavailability and high hepatic degradation. Solubility of Telmisartan in oily phase and surfactant was determined first to identify the components of SNEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify selected oily phase. Optimized SNEDDS formulation consists of Clove oil, Tween 80 and PEG 400. Optimized batch contains oil to Smix (surfactant-cosurfactant mixture) ratio 1:1 with surfactant to co-surfactant ratio of 2:1. The mean globule size of optimized Telmisartan SNEDDS was found to be 65nm with zeta potential value of +8.45Mv. Globule size and shape was confirmed by TEM analysis. Optimized Optimized SNEDDS formulation of Telmisartan showed more than 80% drug release in 20 minutes. Optimized SNEDDS showed significant improvement in rate of release in Telmisartan dissolution as compared to plain drug.
