Abstract
Author(s): Lakshmi Tripura Kalyani Allada, Girija Sankar Guntuku, Murali Krishna Kumar Muthyala, Midhun Kumar Duddu, Naga Sireesha Golla
To characterize the anticancer activity of bioactive compound obtained from Streptomyces coelicoflavus NBRC (15399T ). It was isolated from oil contaminated naval dockyard soil near Visakhapatnam. It was identified by 16S rRNA sequencing and was used for screening their biosurfactant production. Characters of the biosurfactant were analyzed and their anticancer activity was performed in human breast carcinoma cell line (MCF-7) at different concentrations. The biosurfactant were characterized by TLC, FTIR, 1 H and 13C NMR and Mass spectroscopic methods, identified as mono-rhamnolipid. Anticancer activity performed in the human breast carcinoma cell line at different concentrations of biosurfactants. Among the various concentrations of biosurfactants 80.54% cell inhibition was observed and the IC50 value was 88.602 µg/ml. Based on the findings, the present study concluded that, there is a possibility to develop eco-friendly anticancer drugs from oil contaminated soils.
