Abstract
Author(s): Nita Yadav, Anju Goyal
In the present research work two simple, accurate, precise methods of UV-visible spectrophotometric method was developed and validated for the estimation of Saroglitazar in phamaceutical dosage form. Two methods were used for estimation of Saroglitazar using methanol. Method A involves zero order spectroscopy at absorption maximum of 295nm and Method B involves first order derivative at 319 nm. Overlay linearity graph were taken using different concentration of Saroglitazar. The developed methods were validated according to ICH guidelines. The developed methods were found to be linear in concentration range of 5-30 μg/ml with regression equation Y = 0.028x + 0.007. The mean percentage label claim of Saroglitazar was within the acceptable range. The recovery of the drug was ranged between 99.28-101.58 %. The developed methods were found to be accurate and precise. The % RSD values were within the limits. These methods can be used for the routine analysis of Saroglitazar in pharmaceutical dosage form.
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